Cesium carbonate → HCID 57863099, compound

Participants

Reaction Steps

A similar procedure as described in Example 41, step 1 was used, starting from 4-[3-[6-(3-bromo-5-(propane-2-sulfonyl)-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (175 mg, 0.26 mmol), 4-fluoro-phenylboronic acid (73 mg, 0.52 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (29 mg, 0.039 mmol), and cesium carbonate (172 mg, 0.52 mmol) to afford 4-[2-(2-ethoxycarbonyl-ethyl)-3-[6-(5-(propane-2-sulfonyl)-4′-fluoro-biphenyl-3-yloxy)-hexyl]-phenoxy]-butyric acid ethyl ester (180 mg, 99%) as a colorless viscous oil: ES(+)-HRMS m/e calcd for C38H49FO8S (M+Na)+ 707.3024, found 707.3020.

Provenance & Evidence