HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 7-chloro-5-(4-chloro-phenyl)-pyrazolo[1,5-a]pyrimidine → 5-(4-Chloro-phenyl)-7-propyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 7-chloro-5-(4-chloro-phenyl)-pyrazolo[1,5-a]pyrimidine | HCID 87090264 | — |
| Reactant | HCID 178420657 | HCID 178420657 | — |
| Reactant | HCID 178420662 | HCID 178420662 | — |
| Reactant | HCID 178461633 | HCID 178461633 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Product | 5-(4-Chloro-phenyl)-7-propyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid | HCID 66650549 | — |
Reaction Steps
Subjecting ethyl 7-chloro-5-(4-chloro-phenyl)-pyrazolo[1,5-a]pyrimidine in analogous manner to the procedure described in Example C.26, but replacing the ethylzinc chloride/THF solution by a 0.4 M propylzinc chloride/THF solution (freshly prepared from ethylmagnesium chloride and zinc chloride), the title compound was obtained. White solid. MS (ISN) 314.1 [(M−H)−]; mp 208° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093263B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-34f4eb1891ad4ed7b9de791f94a730fd |
| Source note | uspto-grants-2012_01 |