HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 131715448, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | [1-{[5-(2-Fluoro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-carbamoyl}-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester | HCID 19766221 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 131715448 | HCID 131715448 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
1-Methyl-2-[2-((1,1-dimethylethoxy)carbonyl)amino-3-(1H-indol-3-yl)propanoyl]aminomethyl-5-(2'-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine (50 mg, 0.08 mmole) was dissolved in 2 ml of ethyl acetate, cooled to 0° C. and treated with hydrogen chloride gas for 1 hour. The solvent and excess hydrogen chloride were removed under reduced pressure to give the product as a foam which was 96% pure by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04724237 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-83875325c1ee4a0ea07fd297824b70f1 |
| Source note | uspto-grants-1988_02 |