HCID 58455289, compound → 1,3-Dihydroxypropan-2-yl phenyl succinate

HRID 41827Notes

Reaction equation

HRID 41827 reaction equation
[C:1]([O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)(=[O:19])[CH2:2][CH2:3][C:4]([O:6][CH:7]1[CH2:12][O:11]C(C2C=CC=CC=2)[O:9][CH2:8]1)=[O:5]>C(O)C.[Pd]>[C:4]([O:6][CH:7]([CH2:12][OH:11])[CH2:8][OH:9])(=[O:5])[CH2:3][CH2:2][C:1]([O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:19]

Participants

4

Reactant 1

HCID 58455289HCID 58455289, compound

Product 1

HCID 584552561,3-Dihydroxypropan-2-yl phenyl succinate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Phenyl 2-phenyl-1,3-dioxan-5-yl succinate (0.11 g, 0.3 mmol) was dissolved in ethanol (20 ml) under argon and Pd/C (0.09 g, 0.1 mmol) was added. The flask was flushed with hydrogen and allowed to stir under 1 atm H2 at room temperature for 16 h. The crude reaction mixture was passed through a plug of celite and the solvent was removed under reduced pressure yielding (0.9 g, 0.26 mmol, 89%). The product was used without any further purification.

Workup

  1. customThe flask was flushed with hydrogen
  2. customThe crude reaction mixture
  3. customthe solvent was removed under reduced pressure
  4. customyielding (0.9 g, 0.26 mmol, 89%)
  5. customThe product was used without any further purification

Sources & evidence

ORD record
ord-3c4db04d025a4a348b07f1c720ab1e55
Source dataset
uspto-grants-2013_09
Patent number
US08535655B2

Reaction notes

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