Water → 1,1-dimethylethyl(3S)-3-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate

Beteiligte Stoffe

Reaktionsschritte

To a solution of 1,1-dimethylethyl(3S)-3-methyl-1-piperazinecarboxylate (2.05 g, 10.2 mmol) in DCM (50 ml) was added DIPEA (2.68 ml, 15.4 mmol) and the mixture stirred at rt for 10 minutes before addition of 4-(trifluoromethyl)benzenesulfonyl chloride (3.00 g, 12.3 mmol) at 0° C. The resultant mixture stirred under an atmosphere of argon for 16 hours before addition of water (50 ml) and DCM (30 ml). The layers were separated using a hydrophobic frit and the organic layers concentrated to dryness giving the title compound (4.40 g) as a white solid.

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