反应详情

To a solution of 1,1-dimethylethyl(3S)-3-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate (may be prepared as described in Description 5) (4.40 g, 10.8 mmol) in 1,4-dioxane (30 ml) was added HCl (4M in 1,4-dioxane) (5.39 ml, 21.6 mmol) and the mixture stirred at rt for 2 hours. A further portion of HCl (4M in 1,4-dioxane) (16.2 ml, 64.6 mmol) was then added and the mixture stirred for a further 16 hours. The volatiles were then removed in vacuo to give the title compound (3.80 g) as a white solid.

1. stirringthe mixture stirred for a further 16 hours
2. customThe volatiles were then removed in vacuo