Water → 3-{[4-({4-[(Trifluoromethyl)oxy]phenyl}sulfonyl)-1-piperazinyl]carbonyl}pyrazolo[1,5-a]pyrimidine

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Reaction Steps

To a solution of 1-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)piperazine (may be prepared as described in Description 11) (300 mg, 0.967 mmol) in DMF (15 ml) was added pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (158 mg, 0.967 mmol), HOBT.H2O (148 mg, 0.967 mmol) and HBTU (368 mg, 0.967 mmol). Finally DIPEA (0.507 ml, 2.90 mmol) was added and the reaction mixture was stirred at rt for 20 hours. Solvent was removed by evaporation, the crude material partitioned between DCM (50 ml) and saturated sodium bicarbonate (50 ml), the DCM layer collected, washed with 2N HCl aq. (50 ml), dried (hydrophobic frit) and evaporated. The crude was purified by MDAP. MDAP fractions were evaporated and the crude material partitioned between DCM (20 ml) and sat. sodium bicarbonate solution (20 ml). The DCM layer was collected and dried (hydrophobic frit) and evaporated to give the title compound (308 mg).

Provenance & Evidence