Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | HCID 25057408 | HCID 25057408 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | Formate | HCID 283 | 28% |
| Product | HCID 25057932 | HCID 25057932 | — |
Reaction Steps
Compound 33 (80 mg, 0.188 mmol), (Example 8), was dissolved in formic acid (0.5 mL) and formaldehyde (0.5 mL, 37% aqueous solution) was added. The resulting mixture was heated at 70° C. overnight. The solvents were evaporated and the product was purified by preparative HPLC using an acetonitrile/water/formic acid gradient providing the title compound as a formate salt (23 mg, 28% yield), MS analysis electrospray, 440 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08093266B2 |
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| Source dataset | uspto-grants-2012_01 |
|---|
| ORD ID | ord-58b00b0d2cad4db8b5807004fa11bbab |
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| Source note | uspto-grants-2012_01 |
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