Thionyl Chloride → HCID 13637165, compound

HRID 418354Notes

Reaction equation

HRID 418354 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH2:7][CH2:8]O)=[CH:5][N:6]=1.S(Cl)([Cl:12])=O>>[Cl:12][CH2:8][CH2:7][C:4]1[S:3][C:2]([NH2:1])=[N:6][CH:5]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 136371842-(2-Amino-1,3-thiazol-5-yl)ethan-1-ol

Product 1

HCID 13637165HCID 13637165, compound

Conditions

Temperature
62 °C

Procedure

To a suspension of 2-(2-amino-thiazol-5-yl)-ethanol (0.844 g, 5.853 mmol) was added thionyl chloride (3 mL). The mixture was heated at 62° C. for 1 h. The volatiles were removed under reduced vacuum. The residue was co-evaporated with toluene (3×5 mL) to give 0.963 g of 5-(2-chloro-ethyl)-thiazol-2-ylamine crude 5-(2-chlorothyl)-2-thiazolamine monohydrochloride as brown oil.

Workup

  1. customThe volatiles were removed under reduced vacuum

Sources & evidence

ORD record
ord-153a5e9f21414dfc890d479ec2558f2e
Source dataset
uspto-grants-2012_01
Patent number
US08093266B2

Reaction notes

Loading…