Methanol → (R)-2-Amino-5,5,5-trifluoropentanamide hydrochloride

Participants

Reaction Conditions

Reaction Steps

To a suitable pressure vessel, (R)-5,5,5-trifluoro-2-((R)-1-phenylethylamino)-pentanamide hydrochloride (1.50 kg) was charged along with methanol (15.0 L). This was followed by the addition of water (701.0 mL) followed by 20% palladium hydroxide on carbon (225 g). Similarly, palladium on carbon (Pd/C) could be used as the hydrogenation catalyst. The vessel was flushed with nitrogen three times, and then hydrogen gas was pressurized into the vessel (3-4 kg/cm2) at 60° C. The reaction was monitored for completion by HPLC. Upon completion, the reaction mixture was allowed to cool to 30-35° C. and filtered through a CELITE® pad, then washed with methanol. The filtrate was then concentrated under reduced pressure. After complete concentration, the remaining reaction mixture was treated with dichloromethane (2.5 L per wash), filtered and dried at 45° C. for 12 hours, giving the title compound (915 g, 91.0%; Purity=97%). 1H NMR (DMSO-d6) (400 MHz) δ 2.00 (m, 2H, CH2), 2.30-2.40 (m, 2H of CH2-CF3), 3.85-3.88 (m, 1H, —(CONH2)CH(NH), 7.64 & 8.11 (br s, 1H, each of CONH2), 8.44 (br s, 3H, NH3+). 13C NMR (DMSO-d6) (100.0 MHz) δ 169.57, 131.20, 128.45, 125.71, 122.97, 50.91, 29.46, 29.18, 28.89, 28.61, 23.56, 23.53.

Provenance & Evidence