HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 418439Generated: October 26, 2026
4,7-Dichloroquinoline → 7-Chloro-4-(2-methyl-5-nitro-1H-indol-3-yl)-quinoline, hydrochloride
https://huagongshe.com/reaction/418439
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4,7-Dichloroquinoline | HCID 6866 | — |
| Reactant | 2-Methyl-5-nitro-1H-indole | HCID 280313 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 7-Chloro-4-(2-methyl-5-nitro-1H-indol-3-yl)-quinoline, hydrochloride | HCID 131729352 | 95.6% |
Reaction Steps
A mixture of 2-methyl-5-nitroindole (1.34 g) and 4,7-dichloroquinoline (1.53 g) in NMP (1 ml) and 4M HCl in dioxane (0.1 ml) was heated at 145° C. for 2 hours and at 160° C. for 4 hours. After cooling the mixture triturated with ether and the solid collected to give the sub-title compound (2.72 g) as a green solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08093278B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-8782189cd65e4c2b9bd14634dca9706f |
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| Source note | uspto-grants-2012_01 |
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