反应详情

温度

140 °C

A mixture of 5-methoxy-2-methylindole (346 mg) and 4-chloro-8-trifluoromethylquinoline (380 mg) in NMP (1 ml) and 4M HCl in dioxane (0.1 ml) was heated at 140° C. for 50 min. Aqueous sodium bicarbonate was added and the mixture was extracted with ethyl acetate. The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-acetone as eluent) to give the sub-title compound (465 mg).

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialThe organic extracts were dried (MgSO4)
3. customevaporated
4. custompurified by chromatography (silica, petrol-acetone as eluent)