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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 418442Generated: October 25, 2026

4-Chloro-8-(trifluoromethyl)quinoline → 4-(5-fluoro-2-methyl-1H-indol-3-yl)-8-(trifluoromethyl)-quinoline

https://huagongshe.com/reaction/418442

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-8-(trifluoromethyl)quinolineHCID 90262—
Reactant5-Fluoro-2-methylindoleHCID 2778715—
Product4-(5-fluoro-2-methyl-1H-indol-3-yl)-8-(trifluoromethyl)-quinolineHCID 68458434—

Reaction Steps

The sub-title compound was prepared from 5-fluoro-2-methylindole and 4-chloro-8-trifluoromethylquinoline by the method of Example 31, step a).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08093278B2
Source datasetuspto-grants-2012_01
ORD IDord-85f86c59b6a1488f88f169a476f79f6e
Source noteuspto-grants-2012_01