5-Fluoro-2-methylindole → Quinoline,4-(5-fluoro-2-methyl-1h-indol-3-yl)-8-methyl-

HRID 418443Notes

Reaction equation

HRID 418443 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH3:11])=[CH:5]2.Cl[C:13]1[C:22]2[C:17](=[C:18]([CH3:23])[CH:19]=[CH:20][CH:21]=2)[N:16]=[CH:15][CH:14]=1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH3:11])=[C:5]2[C:13]1[C:22]2[C:17](=[C:18]([CH3:23])[CH:19]=[CH:20][CH:21]=2)[N:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 27787155-Fluoro-2-methylindoleHCID 123263354-Chloro-8-methylquinoline

Product 1

HCID 68455910Quinoline,4-(5-fluoro-2-methyl-1h-indol-3-yl)-8-methyl-

Procedure

The sub-title compound was prepared from 5-fluoro-2-methylindole and 4-chloro-8-methylquinoline by the method of Example 31, step a).

Sources & evidence

ORD record
ord-5f2f83d182ad425aa73f4db0587a62eb
Source dataset
uspto-grants-2012_01
Patent number
US08093278B2

Reaction notes

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