2,5-Dimethyl-1H-indole → 8-methanesulphonyl-(2,5-dimethyl-1H-indol-3-yl)quinoline

HRID 418449Notes

Reaction equation

HRID 418449 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([CH3:11])=[CH:6][CH:5]=2.[CH3:12][S:13]([C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:25]=1[N:24]=[CH:23][CH:22]=[C:21]2Cl)(=[O:15])=[O:14]>>[CH3:12][S:13]([C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:25]=1[N:24]=[C:23]([C:10]1[C:9]3[C:4](=[CH:5][CH:6]=[C:7]([CH3:11])[CH:8]=3)[NH:3][C:2]=1[CH3:1])[CH:22]=[CH:21]2)(=[O:15])=[O:14]

Participants

3

Reactant 2

HCID 709652,5-Dimethyl-1H-indoleHCID 147926104-Chloro-8-(methylsulfonyl)quinoline

Product 1

HCID 684588518-methanesulphonyl-(2,5-dimethyl-1H-indol-3-yl)quinoline

Procedure

The sub-title compound was prepared by the method of Example 40 step a, using 2,5-dimethyl indole and 8-methanesulphonyl-4-chloroquinoline.

Sources & evidence

ORD record
ord-092ba134455642dda2229769262e9657
Source dataset
uspto-grants-2012_01
Patent number
US08093278B2

Reaction notes

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