5-Fluoro-2-methylindole → 4-(5-fluoro-2-methyl-1H-indol-3-yl)-8-(methylsulfonyl)-quinoline

HRID 418467Notes

Reaction equation

HRID 418467 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH3:11])=[CH:5]2.[CH3:12][S:13]([C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:25]=1[N:24]=[CH:23][CH:22]=[C:21]2Cl)(=[O:15])=[O:14]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH3:11])=[C:5]2[C:21]1[C:20]2[C:25](=[C:16]([S:13]([CH3:12])(=[O:14])=[O:15])[CH:17]=[CH:18][CH:19]=2)[N:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 27787155-Fluoro-2-methylindoleHCID 147926104-Chloro-8-(methylsulfonyl)quinoline

Product 1

HCID 684572684-(5-fluoro-2-methyl-1H-indol-3-yl)-8-(methylsulfonyl)-quinoline

Procedure

The sub-title compound was prepared by the method of Example 40 step a, using 5-fluoro-2-methyl-1H-indole and 8-methanesulphonyl-4-chloroquinoline.

Sources & evidence

ORD record
ord-86a98616fcaf40358a5013f132ab0463
Source dataset
uspto-grants-2012_01
Patent number
US08093278B2

Reaction notes

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