Dimethylformamide → HCID 59515876, compound

Participants

Reaction Conditions

Reaction Steps

A pressure tube (150 mL) was charged with methyl 4-bromo-2-methyl-3-nitrobenzoate (2.1 g, 0.0077 mol), 1,1-dimethoxy-N,N-dimethylmethanamine (3.6 mL, 0.027 mol) and N,N-dimethylformamide (5 mL, 0.06 mol). The mixture was heated at 120° C. for 20 hours the solvent was removed under reduced pressure and the residue was dissolved in ethyl acetate (100 mL, 1 mol). Silica Gel (20 g, 0.3 mol) was then added and the reaction was stirred at room temperature for 12 h. The reaction was filtered and the solvent was removed and the residue was purified by flash chromatography to afford the desired product. MS m/z=271.2 (M+H).

Provenance & Evidence