Acetic Acid → HCID 59845732, compound

Participants

Reaction Steps

To a mixture of sodium (0.2 g, 0.009 mol) and ethanol (5 mL, 0.08 mol) was added a solution of nitromethane (0.77 g, 0.013 mol) and 4,4-dimethyl-cyclohexanone (1 g, 0.008 mol) in ethanol (1 mL) dropwise. The mixture was stirred at room temperature for 4 hours. Acetic acid (2 mL) and water (10 mL) were added and the mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate (200 mL), washed with brine (30 mL×3), dried over sodium sulfate, and purified by flash chromatography to afford the desired product as a clear oil. (1.5 g, 90%).

Provenance & Evidence