HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 418481Generated: October 26, 2026
Methanol → (R)-2-(1-hydroxypropan-2-yl)-5-nitroisoquinolin-1(2H)-one
https://huagongshe.com/reaction/418481
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (R)-(-)-2-Amino-1-propanol | HCID 80308 | — |
| Reactant | 5-nitro-1H-isochromen-1-one | HCID 10012760 | — |
| Product | (R)-2-(1-hydroxypropan-2-yl)-5-nitroisoquinolin-1(2H)-one | HCID 59515694 | 40% |
Reaction Steps
A 250 mL round bottom flask was charged with 5-nitro-isochromen-1-one (40 g, 0.2 mol), (2R)-2-Aminopropan-1-ol (18 g, 0.24 mol), triethylamine (100 mL, 0.7 mol) and methanol (500 mL, 10 mol) and the reaction heated at 88° C. for 1.5 hours. The product precipitated out upon cooling the reaction and was filtered to afford the product as a yellow solid. (17.3 g, 40% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08093265B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-276a6ba1188e448898e2a550dfa68f05 |
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| Source note | uspto-grants-2012_01 |
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