Dichloromethane → (R)-2-(6-Methyl-5-nitro-1-oxoisoquinolin-2(1H)-yl)propyl acetate

Participants

Reaction Steps

To a solution of (R)-2-(1-hydroxypropan-2-yl)-6-methyl-5-nitroisoquinolin-1 (2H)-one (4.8 g, 0.018 mol) in methylene chloride (100 mL, 2 mol) was added acetic anhydride (7 g, 0.07 mol), triethylamine (10 g, 0.1 mol) and 4-Dimethylaminopyridine (20 mg, 0.0002 mol). The mixture was stirred at room temperature for 1 hour, washed with 1N hydrochloric acid and brine, and dried. The volatiles were removed under reduced pressure and the residue was purified by column chromatography to afford a yellow-brown oil.

Provenance & Evidence