HRID418495
反应详情
EQUATION
反应方程式
REACTANTS
反应物
HCID6228
N,N-Dimethylformamide
C3H7NO
HCID81531
Diisopropylethylamine
C8H19N
HCID118342
(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acid
C9H7F3O2
HCID9886157
Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
C10H15F6N6OP
HCID58973961
未命名化合物
PRODUCTS
生成物
CONDITIONS
反应条件
- 温度
- 60 °C
PROCEDURE
实验过程
A mixture of (S)-2-(5-amino-6-chloro-1-oxoisoquinolin-2(1H)-yl)propanamide (100.0 mg, 0.0003764 mol), 2-(4-(trifluoromethyl)phenyl)acetic acid (115.2 mg, 0.0005646 mol), N,N-diisopropylethylamine (163.9 μL, 0.0009409 mol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (357.8 mg, 0.0009409 mol) and N,N-dimethylformamide (2 mL, 0.02 mol) was stirred at 60° C. for 3 days. the solvent was removed under reduced pressure and the residue purified by reverse phase preparative HPLC to afford the product as light yellow solid.
WORKUP
后处理
- customthe solvent was removed under reduced pressure
- customthe residue purified by reverse phase preparative HPLC