HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 418498Generated: October 30, 2026
Methanol → (R)-6-Chloro-2-(1-hydroxypropan-2-yl)-5-nitroisoquinolin-1(2H)-one
https://huagongshe.com/reaction/418498
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (R)-(-)-2-Amino-1-propanol | HCID 80308 | — |
| Reactant | 6-Chloro-5-nitro-1H-isochromen-1-one | HCID 59515725 | — |
| Product | (R)-6-Chloro-2-(1-hydroxypropan-2-yl)-5-nitroisoquinolin-1(2H)-one | HCID 59515901 | — |
Reaction Steps
A microwave vial was charged with 6-chloro-5-nitro-1H-isochromen-1-one (80.0 mg, 0.000355 mol), (2R)-2-aminopropan-1-ol (29 mg, 0.00039 mol), triethylamine (0.15 mL, 0.0011 mol) and methanol (4 mL, 0.1 mol), and heated under microwave irradiation at 100° C. for 30 minutes. the solvent was removed under reduced pressure and the residue purified by flash chromatography to afford the desired product as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08093265B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-efa0e4624c484d9198d3abb0392db6bf |
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| Source note | uspto-grants-2012_01 |
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