反应详情

A round bottom flask was charged with (R)-2-(6-cyclopropyl-5-nitro-1-oxoisoquinolin-2(1H)-yl)propyl acetate (28 mg, 0.000085 mol), ethanol (10 mL, 0.2 mol) and palladium, 10% weight on charcoal (1.0 mg, 0.0000085 mol) was added. The flask was evacuated and flushed with hydrogen two times and the reaction was stirred under hydrogen (1 atm) for 2 hours. The reaction was filtered over celite and the solvent was removed to afford the product.

1. additionwas added
2. customThe flask was evacuated
3. customflushed with hydrogen two times
4. filtrationThe reaction was filtered over celite
5. customthe solvent was removed
6. customto afford the product