HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 418508Generated: October 29, 2026
Dichloromethane → HCID 59515734, compound
https://huagongshe.com/reaction/418508
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Fluoro-3-(trifluoromethyl)phenylacetic acid | HCID 2737588 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 59515926 | HCID 59515926 | — |
| Product | HCID 59515734 | HCID 59515734 | — |
Reaction Steps
A reaction vial was charged with acetic acid 2-[6-(2-acetoxy-ethylamino)-5-amino-1-oxo-1H-isoquinolin-2-yl]-ethyl ester (100.00 mg, 0.000 28788 mol), 2-(2-fluoro-3-(trifluoromethyl)phenyl)acetic acid (76.74 mg, 0.0003454 mol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (274 mg, 0.000720 mol), N,N-diisopropylethylamine (0.125 mL, 0.000720 mol) and methylene chloride (3 mL, 0.05 mol). The reaction was heated at 40° C. for 5 h. The solvent was removed under reduced pressure and the residue purified by flash chromatography to afford the product as an off white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08093265B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-965c78c69e29449498414671df6a509a |
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| Source note | uspto-grants-2012_01 |
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