Methanol → HCID 25012310, compound

Participants

Reaction Steps

A round bottom flask was charged with (S)-2-(5-(2-(3-fluoro-4-(trifluoromethyl)phenyl)-acetamido)-6-methyl-1-oxoisoquinolin-2(1H)-yl)propyl acetate (200.00 mg, 0.41803 mmol), potassium carbonate (173 mg, 0.00125 mol), methanol (15 mL, 0.37 mol) and few drops of water. The reaction was stirred at room temperature for 1 h. The reaction mixture was filtered and the solvent was removed under reduced pressure. The residue was extracted with IPA:chloroforn, 1:3, washed with water and the solvent was removed under reduced pressure. The residue was purified by reverse phase prep HPLC to give the desired compound as light orange solid.

Provenance & Evidence