Methanol → (R)-2-(1-Hydroxycycloheptyl)-N-(2-(1-hydroxypropan-2-yl)-6-methyl-1-oxo-1,2-dihydroisoquinolin-5-yl)acetamide

Participants

Reaction Steps

A round bottom flask was charged with (R)-2-(5-(2-(1-hydroxycycloheptyl)acetamido)-6-methyl-1-oxoisoquinolin-2(1H)-yl)propyl acetate (100.00 mg, 0.14 mmol), potassium carbonate (58.0 mg, 0.000420 mol) and methanol (4 mL, 0.1 mol) and the reaction mixture stirred at room temperature 1 hour. The solvent was removed under reduced pressure and the residue was purified by reverse phase preparative HPLC to afford the product.

Provenance & Evidence