Dichloromethane → (R)-2-(3-Fluoro-4-(trifluoromethyl)phenyl)-N-(6-methyl-2-(1-(methylamino)propan-2-yl)-1-oxo-1,2-dihydroisoquinolin-5-yl)acetamide

Participants

Reaction Steps

A solution of (R)—N-(2-(1-(allyl(methyl)amino)propan-2-yl)-6-methyl-1-oxo-1,2-dihydroisoquinolin-5-yl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide (56 mg, 0.00011 mol) in methylene chloride (2.5 mL, 0.039 mol) was added to 1,3-dimethylbarbituric acid (60 mg, 0.0004 mol) and tetrakis(triphenylphosphine)palladium(0) (1 mg, 0.000001 mol) under argon. The mixture was stirred at room temperature for 4 hours, purified via flash chromatography and then by reverse phase preparative HPLC to afford the desired product as a white solid.

Provenance & Evidence