HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → (R)-6-Chloro-N-((4,4-difluorocyclohexyl)methyl)-2-(1-hydroxypropan-2-yl)-1-oxo-1,2-dihydroiso-quinoline-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (R)-2-(6-Chloro-5-((4,4-difluorocyclohexyl)methylcarbamoyl)-1-oxoisoquinolin-2(1H)-yl)propyl acetate | HCID 59845735 | — |
| Product | (R)-6-Chloro-N-((4,4-difluorocyclohexyl)methyl)-2-(1-hydroxypropan-2-yl)-1-oxo-1,2-dihydroiso-quinoline-5-carboxamide | HCID 25014111 | — |
Reaction Steps
(R)-2-(6-Chloro-5-((4,4-difluorocyclohexyl)methylcarbamoyl)-1-oxoisoquinolin-2(1H)-yl)propyl acetate (140 mg, 0.00029 mol) and potassium carbonate (140 mg, 0.0010 mol) were stirred in methanol (6 mL, 0.1 mol) at room temperature for 1 hour, concentrated, purified by reverse phase preparative HPLC to afford the desired product as a white solid. (77 mg, 63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093265B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-83d6e3cc8ee746dcb8a462ca84863439 |
| Source note | uspto-grants-2012_01 |