Dichloromethane → 2-(3-Fluoro-4-trifluoromethyl-phenyl)-N-{2-[(R)-2-(3-hydroxy-azetidin-1-yl)-1-methyl-ethyl]-6-methyl-1-oxo-1,2-dihydro-isoquinolin-5-yl}-acetamide

Participants

Reaction Steps

A solution of (R)-2-(5-(2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamido)-6-methyl-1-oxoisoquinolin-2(1H)-yl)propyl methanesulfonate (100 mg, 0.2 mmol), 3-hydroxyazetidine hydrochloride (120 mg, 1.1 mmol), triethylamine (200 mg, 2 mmol) and methylene chloride (1 mL, 20 mmol) was stirred at room temperature overnight. The volatiles were removed and the residue was purified by reverse phase preparative HPLC to afford the desired product as a white solid.

Provenance & Evidence