7-Chloro-5-nitro-1H-indole → HCID 15453465, compound

Participants

Reaction Steps

Pd/C (DeGussa catalyst) (192 mg) was added to a solution of 7-chloro-5-nitro-1H-indole (Synthesis 2004, 4, 610-618) (765 mg, 3.9 mmol) in EtOH (15 mL) at room temperature and the reaction mixture was stirred under hydrogen atmosphere (1 atm.) for 3 hours. The catalyst was then filtered off on a celite pad and the filtrate was evaporated under reduced pressure to give a dark oil. This crude material was purified by flash chromatography (0% to 20% of MeOH in DCM) to give 648 mg (60% yield) of 7-chloro-1H-indol-5-ylamine.

Provenance & Evidence