反应详情

2.33 g (8.56 mmol) of 3-fluoro-2-methyl-4-(pentafluoroethyl)benzoic acid were introduced into 30 ml of methanol and admixed with 2 ml of concentrated sulfuric acid. The mixture was subsequently heated at reflux until a check by HPLC indicated full conversion. The contents were freed from the solvent, and the residue was taken up in water. The mixture was extracted twice with ethyl acetate, and the combined organic phases were washed once with saturated aqueous sodium hydrogen-carbonate solution. The organic phase was dried and freed from the solvent. The residue obtained was 2.1 g of clean product.

1. temperatureThe mixture was subsequently heated
2. temperatureat reflux until a check by HPLC
3. extractionThe mixture was extracted twice with ethyl acetate
4. washthe combined organic phases were washed once with saturated aqueous sodium hydrogen-carbonate solution
5. customThe organic phase was dried
6. customThe residue obtained