Ethyl 2-(3-Fluoro-4-(2-(3-methoxy-4-(2-morpholinoethoxy)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-2-oxoacetate → Ethyl 2-(3-fluoro-4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-2-oxoacetate

HRID 418648Notes

Reaction equation

HRID 418648 reaction equation
[CH2:1]([N:3]1[CH:7]=[C:6]([C:8]2[S:16][C:15]3[C:10](=[N:11][CH:12]=[CH:13][C:14]=3[O:17][C:18]3[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][C:19]=3[F:25])[CH:9]=2)[N:5]=[CH:4]1)[CH3:2].FC1C=C(N[C:61](=[O:67])[C:62]([O:64][CH2:65][CH3:66])=[O:63])C=CC=1OC1C=CN=C2C=C(C3C=CC(OCCN4CCOCC4)=C(OC)C=3)SC=12>>[F:25][C:19]1[CH:20]=[C:21]([NH:24][C:61](=[O:67])[C:62]([O:64][CH2:65][CH3:66])=[O:63])[CH:22]=[CH:23][C:18]=1[O:17][C:14]1[CH:13]=[CH:12][N:11]=[C:10]2[CH:9]=[C:8]([C:6]3[N:5]=[CH:4][N:3]([CH2:1][CH3:2])[CH:7]=3)[S:16][C:15]=12

Participants

3

Reactant 2

HCID 58790158Ethyl 2-(3-Fluoro-4-(2-(3-methoxy-4-(2-morpholinoethoxy)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-2-oxoacetateHCID 594244554-(2-(1-Ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorobenzenamine

Product 1

HCID 58790366Ethyl 2-(3-fluoro-4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-2-oxoacetateYield 14%

Procedure

Starting from the amine 15 (scheme 4) and following the same procedure as described for the synthesis of compound 140 (scheme 40), title compound 142 was obtained as white solid in 14% yield. MS (m/z): 455.1 (M+H).

Sources & evidence

ORD record
ord-41876b7db3d04eb4a49bd06ee0cb2a10
Source dataset
uspto-grants-2012_01
Patent number
US08093264B2

Reaction notes

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