反应详情

The hydroxy-compound 147 (685 mg, 1.73 mmol) was suspended in thionyl chloride (8.6 mL) and the reaction mixture was refluxed for about one hour. The mixture was cooled to RT then poured into an ice/water mixture. The resultant solid was collected by filtration, washed with water and well dried to afford title compound 148 as a yellow solid (730 mg, 93% yield). MS (m/z): 415.0 (M+H).

1. temperaturethe reaction mixture was refluxed for about one hour
2. filtrationThe resultant solid was collected by filtration
3. washwashed with water
4. customwell dried