Ammonium Chloride → HCID 58790403, compound

Participants

Reaction Steps

To a solution of nitro compound 169 (400 mg, 0.88 mmol) in EtOH/H2O (8 mL/4 mL) at 100° C. (bath) was added iron powder (420 mg, 7.48 mmol) and NH4Cl (41 mg, 0.76 mmol) and the reaction mixture was stirred vigorously at reflux temperature for an hour. The mixture was cooled to room temperature and filtered through a Celite pad. The filtrate was collected and concentrated to give the title compound 170 (4.20 mg, 88% purity) as a yellow solid. MS (m/z): 424.0 (M+H).

Provenance & Evidence