反应详情

温度

100 °C

2-Chloro-3-pyridinecarboxaldehyde (4.04 g, 2.86 mmol) and 4-fluorobenzenesulfinic acid sodium salt (5.73 g, 3.14 mmol) were dissolved in DMSO (100 ml) and the mixture was heated at 100° C. for 72 h under nitrogen. Upon cooling to ambient the mixture was diluted with water (500 ml) and extracted with EtOAc (3×). The combined organics were washed with water, brine, dried (MgSO4) and evaporated to dryness to afford 7.89 g of crude product. The crude compound was pre-absorbed onto silica and purified by dry pad suction column chromatography, eluting with heptane using an EtOAc gradient, to afford 4.14 g (41%) of the desired product as a yellow solid (plates) (MP=131-131.3° C.; IR=1691 cm−1; HPLC=7.21 min>99%).

1. temperatureUpon cooling to ambient the mixture
2. extractionextracted with EtOAc (3×)
3. washThe combined organics were washed with water, brine
4. dry with materialdried (MgSO4)
5. customevaporated to dryness
6. customto afford 7.89 g of crude product
7. customThe crude compound was pre-absorbed onto silica
8. custompurified
9. customby dry pad suction column chromatography
10. washeluting with heptane using an EtOAc gradient