Ammonium Chloride → 3-Fluoro-4-((2-iodothieno[3,2-b]pyridin-7-yl)oxy)aniline

Participants

Reaction Steps

To a solution of 399 (2 g, 4.81 mmol) and NH4Cl (220 mg, 4.08 mmol) in 2:1 EtOH/water (75 mL) was added iron powder (2.28 g, 40.8 mmol) and the suspension was heated to reflux for 1 hour. The reaction mixture was filtered through celite and concentrated to afford 410 (1.85 g, 100% yield), that was used without further purification MS. (m/z): (M+1) 386.8 (100%).

Provenance & Evidence