(2R)-4-(2,3-Dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-({[(1R)-1-phenylethyl]amino}methyl)-2-pentanol → (2R)-2-(Aminomethyl)-4-(2,3-dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-pentanol

Participants

Reaction Steps

(2R)-4-(2,3-Dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-({[(1R)-1-phenylethyl]amino}methyl)-2-pentanol (Intermediate 23, (480 mg, 1.178 mmol) was dissolved in EtOH (13 mL) and hydrogenated over 10% palladium on charcoal (119 mg) at 50 psi and room temperature for 5 hours. Catalyst was removed by filtration through a microfibre filter pad and Celite. The Celite was washed several times with EtOH. The filtrate was evaporated in vacuo to give the title compound as a pale grey solid (330 mg).

Provenance & Evidence