反应详情

N-Bromosuccinimide (10.4 g, 56.0 mmol) was added portionwise to a solution of 3-(4-chlorophenyl)-1H-pyrazole (10.0 g, 56.0 mmol) in CH2Cl2 (140 mL). The mixture was stirred for 10 min, water and an additional portion of CH2Cl2 were added and the mixture was stirred for 5 min. The organic phase was separated, washed with brine, dried (MgSO4) and concentrated to yield 15.0 g of Ex 3-Step 1 product as a light yellow solid: 1H NMR (400 MHz, CDCl3) δ 7.68 (d, J=8.6, 2H), 7.59 (s, 1H), 7.35-7.39 (m, 2H).

1. stirringthe mixture was stirred for 5 min
2. customThe organic phase was separated
3. washwashed with brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated
6. customto yield 15.0 g of Ex 3-Step 1 product as a light yellow solid