2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane → 1,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-({[1-(4-pyridinyl)-1h-indazol-4-yl]amino}methyl)-2-pentanol

Participants

Role	Name	HCID	Charge
Reactant	2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane	HCID 16099239	—
Reactant	1-(4-Pyridinyl)-1H-indazol-4-amine	HCID 57615957	—
Product	1,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-({[1-(4-pyridinyl)-1h-indazol-4-yl]amino}methyl)-2-pentanol	HCID 57615936	—

Reaction Steps

Prepared similarly to Example 1 from racemic 2-{2-[5-fluoro-2-(methyloxy)phenyl]-2-methylpropyl}-2-(trifluoromethyl)oxirane and 1-(4-pyridinyl)-1H-indazol-4-amine (Intermediate 5).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08093281B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-d98aacb0a5e2445fad96b0c18d5b0ba5
Source note	uspto-grants-2012_01