反应详情

Prepared similarly to Example 25 from 2-(aminomethyl)-1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-pentanol (Intermediate 18) and 4-bromo-1-(4-fluorophenyl)-6-methyl-1H-indazole (Intermediate 28). Purification was conducted by silica gel chromatography using the Flashmaster II (20 g cartridge) eluting with a 100:0 to 50:50 cyclohexane:ethyl acetate gradient over 40 minutes to give the title compound (26.7 mg)

1. customPurification
2. washeluting with a 100:0 to 50:50 cyclohexane