Sodium t-butoxide → Ethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoate

Participants

Reaction Steps

Sodium tert-butoxide (4 mg, 0.042 mmol) was added to a solution of phenylmethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoate (Intermediate 30, 23 mg, 0.035 mmol) in ethanol (3 mL) and the mixture stirred at room temperature for 75 min. The mixture was then partitioned between dichloromethane (20 mL) and aqueous ammonium chloride (20 mL). The organic layer was separated, passed through a hydrophobic frit and evaporated and the residue purified by mass-directed autopreparation to give the title compound (12 mg).

Provenance & Evidence