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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 418811생성일: 2026년 10월 26일

1-(4-methoxyphenyl)-1H-indazol-4-amine → 4-(2,3-Dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-[({1-[4-(methyloxy)phenyl]-1h-indazol-4-yl}amino)methyl]-2-pentanol

https://huagongshe.com/reaction/418811

반응식

참여 물질

역할이름HCID투입량
반응물1-(4-methoxyphenyl)-1H-indazol-4-amineHCID 57615949—
반응물7-[1,1-Dimethyl-2-(2-trifluoromethyloxiranyl)ethyl]-2,3-dihydrobenzofuranHCID 57775518—
생성물4-(2,3-Dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-[({1-[4-(methyloxy)phenyl]-1h-indazol-4-yl}amino)methyl]-2-pentanolHCID 57615932—

반응 단계

Prepared similarly to Example 1 from racemic 7-{1,1-dimethyl-2-[2-(trifluoromethyl)-2-oxiranyl]ethyl}-2,3-dihydro-1-benzofuran (which may be prepared according to WO 04/063163) and 1-[4-(methyloxy)phenyl]-1H-indazol-4-amine (Intermediate 3).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08093281B2
출처 데이터셋uspto-grants-2012_01
ORD IDord-69543ecd4a7a4fdfbe9b3ed9972cffb4
출처 메모uspto-grants-2012_01