Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → HCID 59504500, compound

Participants

Reaction Steps

Reflux a solution of 2-(3-methoxy-phenyl)-cyclopentanone (4.34 g 22.8 mmoles), and (carboethoxymethylene)-triphenylphosphorane (14.31 g, 41.1 mmoles) in 130 ml of xylenes for 15 hours. Concentrate in vacuo at 40° C. and slurry with ether. Remove triphenyl phosphine oxide by vacuum filtration, and chromatographed on silica with 14% ethyl acetate/hexanes. to yield the 4.83 g of the titled compound. 1H NMR (CDCl3): 7.26 (m, 1H), 6.9 (m, 2H), 6.8 (m, 1H), 4.17 (q, J=7.2, 2H), 3.81 (s, 3H), 3.22 (s, 2H), 2.76 (m, 2H), 2.58 (m, 2H), 1.95 (m, 2H) 1.28 (m, 3H).

Provenance & Evidence