HCID 59504489, compound → HCID 59504443, compound

Participants

Reaction Steps

Dissolve 2-(3-methoxy-phenyl)-4,4-dimethyl-cyclohex-2-enone (13 g, 56.4 mmol) in ethanol (500 ml), exchange with N2 3×, and add 10% palladium on activated carbon (0.3 g, 2.82 mmol). Stir under atmospheric pressure of H2 over night. Filter off catalyst and concentrate to give the title compound (13.1 g, 99%): 1H NMR (CDCl3) δ 7.24-7.19 (m, 1H), 6.85-6.64 (m, 3H), 3.78 (s, 3H), 1.97-1.89 (m, 1H), 1.82-1.75 (m, 3H), 1.64-1.55 (m, 1H), 1.25-1.14 (m, 2H), 1.0 (s, 3H), 0.96 (s,3H).

Provenance & Evidence