HCID 59504314, compound → HCID 66652123, compound

Participants

Reaction Steps

Dissolve [2-(3-methoxy-phenyl)-4,4-dimethyl-cyclohex-1-enyl]-acetic acid methyl ester (4.3 g, 15 mmol) in methanol (135 ml), exchange with N2 3×, add palladium hydroxide 20% on activated carbon (0.84 g, 5.9 mmol). Add 60 psi of H2 at room temperature for 18 h. Filter off catalyst rinsing with methanol, concentrate filtrate to give the title compound (3.8 g, 88%): 1H NMR (CDCl3) δ 7.23-7.17 (m, 1H), 6.79-6.71 (m, 3H), 3.80 (s, 3H), 3.55-3.49 (t, 3H), 2.52-2.19 (m, 1H), 1.95-1.83 (m, 2H), 1.72-1.21 (m, 6H), 1.02 (s,3H), 0.99, (s, 3H), 0.93 (s, 1H).

Provenance & Evidence