Triethylamine → HCID 66651956, compound

Participants

Reaction Steps

Combine 3-Methoxy-9-(4-methoxy-phenyl)-4b,5,6,7,8,8a,9,10-octahydro-phenanthrene-1-carboxylic acid amide (0.69 g, 0.19 mmol), and triethylamine (0.038 g, 0.38 mmol) in methylene chloride (2.5 ml) at 0-5° C. and add trifluoroacetic anhydride (0.044 g, 0.21 mmol). Let stir at r.t. for 15 minutes. Add water, separate organic layer. Dry over anhydrous sodium sulfate and remove solvent in vacuo to yield preparation 122 (0.066 g, 100%). 1H NMR (CDCl3): 7.24 (d, J=8.8 Hz, 2H), 7.22 (s, 1H), 7.06 (s, 1H), 6.94 (d, J=8.8, 2H), 3.86 (m, 6H), 3.2 (m, 4H), 2.5 (m, 1H), 2.1 (m, 1H), 1.8-0.8 (m, 7H).

Provenance & Evidence