Dimethylformamide → HCID 66652115, compound

Participants

Reaction Steps

Combine 2-Bromo-9-(4-hydroxy-phenyl)-4b,5,6,7,8,8a,9,10-octahydro-phenanthren-3-ol (chiral) (0.033 g, 0.09 mmol), CuCl2 (0.008 g, 0.06 mmol), 5 M NaOMe (in methanol, 1.5 ml), DMF (0.5 ml) and heat 15 hours at 110° C. Cool, add ethyl acetate and wash with 1N HCl, then water. Dry organic layer over anhydrous sodium sulfate and remove solvent in vacuo. Chromatograph over silica gel 2× first with 20% ethyl acetate/hexanes, then 5-20% ethyl acetate/hexanes to yield the titled compound (0.010 g, 100%). 1H NMR (CDCl3): 7.21 (d, J=8.4 Hz, 2H), 7.0 (s, 1H), 6.85 (d, J=8.8 Hz, 2H), 6.69 (s, 1H), 3.91 (s, 3H), 3.2 (m, 4H), 2.85 (dd, J=4 and 11 Hz, 1H), 2.45 (d, J=14.9 Hz, 1H), 2.1-0.8 (m, 7H). MS m/z 323(M−1).

Provenance & Evidence