Methylamine → HCID 66652234, compound

Participants

Reaction Steps

Combine 5-(4-Hydroxy-phenyl)-1,2,3,4,4a,5,6,8,9,12b-decahydro-11-oxa-benzo[a]anthracen-10-one (0.014 g, 0.04 mmol) and excess methylamine (40% in water) in tetrahydrofuran (1 ml). After 30 minutes, remove solvent in vacuo, dissolve in ethyl acetate and dry over anhydrous sodium sulfate. Remove solvent in vacuo to yield the titled compound (0.014 g, 92%). 1H NMR (DMSO-d6) 9.19 (s, 1H), 9.02 (s, 1H), 7.11 (d, J=8.8 Hz, 2H), 6.83 (s, 1H), 6.79 (s, 1H), 6.73 (d, J=8.4 Hz, 2H), 3.1 (m, 3H), 2.7 (m, 3H), 2.58 (s, 3H), 2.35 (m, 2H), 1.9 (m, 1H), 1.6 (m, 2H), 1.4 (m, 1H), 1.75-0.9 (m, 5H).

Provenance & Evidence