HCID 46318646, compound → HCID 57942434, compound

HRID 419026Notes

Reaction equation

HRID 419026 reaction equation
[CH2:1]([O:3][C:4]1[CH:15]=[CH:14][CH:13]=[CH:12][C:5]=1[C:6](N(OC)C)=[O:7])[CH3:2].Br[C:17]1[C:22]([N:23]([CH2:38][O:39][CH3:40])[S:24]([C:27]2[CH:32]=[CH:31][C:30]([Cl:33])=[C:29]([C:34]([F:37])([F:36])[F:35])[CH:28]=2)(=[O:26])=[O:25])=[CH:21][C:20]([Cl:41])=[CH:19][N:18]=1>>[Cl:33][C:30]1[CH:31]=[CH:32][C:27]([S:24]([N:23]([C:22]2[C:17]([C:6](=[O:7])[C:5]3[CH:12]=[CH:13][CH:14]=[CH:15][C:4]=3[O:3][CH2:1][CH3:2])=[N:18][CH:19]=[C:20]([Cl:41])[CH:21]=2)[CH2:38][O:39][CH3:40])(=[O:26])=[O:25])=[CH:28][C:29]=1[C:34]([F:35])([F:37])[F:36]

Participants

3

Reactant 2

HCID 46318646HCID 46318646, compoundHCID 57942086N-(2-Bromo-5-chloro-pyridin-3-yl)-4-chloro-N-methoxvmethyl-3-trifluoromethyl-benzenesulfonamide

Product 1

HCID 57942434HCID 57942434, compound

Procedure

4-Chloro-N-[5-chloro-2-(2-ethoxy-benzoyl)-pyridin-3-yl]-N-methoxymethyl-3-trifluoromethyl-benzenesulfonamide was prepared from 2-ethoxy-N-methoxy-N-methyl-benzamide and N-(2-bromo-5-chloro-pyridin-3-yl)-4-chloro-N-methoxymethyl-3-trifluoromethyl-benzenesulfonamide according to previously described procedure in example 29. The product was purified by flash column chromatography on silica gel using ethyl acetate-hexane. MS m/z: 562.4 (M+H).

Workup

  1. customThe product was purified by flash column chromatography on silica gel

Sources & evidence

ORD record
ord-3a218eeb439f4230a2f61c74ebfb24a8
Source dataset
uspto-grants-2012_01
Patent number
US08093247B2

Reaction notes

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