HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 419129Generated: October 29, 2026
Hydrochloric Acid → 2-(Methylamino)-3-nitrobenzoic acid
https://huagongshe.com/reaction/419129
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 86610778 | HCID 86610778 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(Methylamino)-3-nitrobenzoic acid | HCID 22569874 | — |
Reaction Steps
A mixture of 2-[methyl-(2,2,2-trifluoro-acetyl)-amino]-3-nitro-benzoic acid methyl ester (1.7 g, 5.5 mmol) and 5 M aqueous NaOH (5 mL) in THF (10 mL) was stirred at 50° C. for several hours. The mixture was acidified with 4 M HCl and extracted with EtOAc to provide 2-methylamino-3-nitro-benzoic acid. MS m/z: 197.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08093247B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-0ac1d23363a844a889c22b171fdb40ba |
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| Source note | uspto-grants-2012_01 |
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